The paper outlines the efforts of Sayaji Rao Gaekwad Library, which belongs to Asia 's largest university system, Banaras Hindu University (BHU), to make their rich collection of manuscripts available to the world of scholars. It also includes an elaboration of the National Mission for Manuscripts of India and the affiliation of Central Library, BHU with it. A detailed account of the Central Library, BHU as Manuscript Conservation Centre is provided. The issues and future targets for the library pertaining to preservation of manuscripts are described. The paper is first to report the gradual evolution of Central Library, BHU as an essential part of the National Mission for Manuscripts, a National initiative by Ministry of Culture, Government of India.