This research work studied the challenges of lecturers towards the use of institutional repositories (IRs) in university libraries in South East, Nigeria. A descriptive survey research design, the population of the study was 167, 32 and the sample size was 305 lecturers respectively. Structured questionnaire was the instrument for data collection; the data collected were analyzed using SPSS, tables and frequency counts. The most used materials in the institutional repositories by lecturers are journal articles, theses and dissertations e.t.c but some find institutional repositories difficult to access and use them. Based on the study it was recommended among others that librarians should use familiar keywords while organizing the institutional repositories for easy access and use of the content.