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The Study was designed to find out the Influence of Koha Software on circulation and serial operations for effective service delivery in university libraries in North Central Nigeria. The study was guided by two specific objectives, two research questions and two hypotheses. Descriptive Survey research design was adopted for the study. The Study area is North Central Nigeria. The population comprises of 650 library staff in 12 public university libraries in North central Nigeria. The sample size for the study was 354 library staff from five (5) public university libraries using Koha in North central Nigeria. Purposive sampling technique was used to select five (5) out of the twelve (12) public university libraries in North Central Nigeria using Koha. Method of data collection was a self developed questionnaire titled: Influence of Koha Software on Circulation and Serial Operations Questionnaire (IKSCOQ). Research question were answered using descriptive statistics of mean and standard deviation while hypothesis was tested using chi-square at 0.05 level of significant. The findings of the study revealed that Koha software packages has significant positive effect on both circulation and serial operations in public university libraries in North Central Nigeria. Based on the results of the findings, the study concluded that, koha software have positive influence on both circulation and serials activities.