E-learning allows for efficient transfer of knowledge in the real-time process, while at the same time empowering learners with the information technology awareness and skills crucial to succeed in the present Knowledge Revolution Era. The world scenario of Library and Information Science (LIS) education is changing fast. The change is enforced by many forces such as technology, demographic features, economic characters, etc. The present paper discussed the concept of e-learning and its application in LIS education. It also emphasized on the potential benefits of implementing e-learning in LIS education in North-East India and equally discussed the challenges that can affect in the adoption of E-learning in LIS education in North East India.