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Coronary artery disease (CAD) is a major cause of death and disability in developed countries. Although CAD mortality rates worldwide have declined over the past 4 decades, CAD remains responsible for approximately one-third or more of all deaths in individuals over age 35, and it has been estimated that nearly half of all middle-aged men and one-third of middle aged women in the United States will develop clinical CAD. The present paper attempts to check the applicability of Lotka’s Law on South African publication on Coronary artery disease research. The study lights on Lotka’s empirical law of scientific productivity, i.e., Inverse Square Law, to measure the scientific productivity of authors, to test Lotka’s Exponent value and the K.S test for the fitness of Lotka’s Law.