This study sought to investigate the availability and utilization of e-resources in university libraries for effective research output by undergraduates of Social Studies in south-east, Nigeria. It is a descriptive survey research design. two research questions guided the study. A sample of 191 students from four stratified randomly selected universities in south east, Nigeria, were used for the study. The instrument for data collection is the researcher’s designed and validated questionnaire, tagged: ‘The Use of E-Resources in University Libraries Questionnaire’ (UERULQ). The instrument was trial tested using Cronbach Alpha, while reliability coefficient of 0.98 was obtained, which was considered high enough for the study. Mean and standard deviation, frequency and standard deviation was used to answer the research questions. The results showed among others that students use e-library resources but not to the maximum because they lack ICT skills and do encounter problems while using them. It concluded among others that when strategies for enhancing the utilization of e-resources suggested in this study were adhered to, it will reduce the problems students encounter in using e-resources for their academic research and ultimately, lead to effective research output. The study recommended among others that the National Universities Commission (NUC), National Commission for Colleges of Education (NCCE) among other educational bodies should be focused towards preparing teachers to acquire appropriate skills in e-resources utilization.