Provision of information services by university libraries to patrons has been around in Nigeria since the establishment of the first university library in 1948 and users ‘satisfaction has been a subject of research. However, .studies on academic self-efficacy in relation to information needs satisfaction of patrons is rare. This study therefore investigated academic self-efficacy and information needs satisfaction of undergraduates in universities in South-West Nigeria. The design for the study was survey, involving multistage sampling technique. Two questionnaires were used to sample 1,086 undergraduates across three faculties in six universities in South-West Nigeria. 1,045 responses were analysed statistically. The study found that academic self-efficacy of undergraduates in universities in South-West Nigeria is high. The students also expressed satisfaction with their university libraries in meeting most of their information needs. There was however low positive (Pearson r = 0.059) relationship between academic self-efficacy and information needs satisfaction of the students. This study concluded that, for academic self-efficacy of undergraduates in universities in South-West Nigeria to be higher, there is need for university administrators to make learning environment more conducive and make provision for more facilities on campuses. Also, university libraries should embark on extensive user education to equip users with the requisite skills needed to maximize the use of and satisfaction with the services provided.