Library is the indispensable part of educational institution designed to serve educational, cultural, research, recreational information to the users. . Libraries are the places wherever the complete information gathering takes place together with intellectual and our cultural heritage. The collections possessed by the library are affected by numerous environmental factors that ultimately results in irreparable harm to numerous collections. The information embodied in manuscripts is effective however materials used for this purpose cause a true challenge. These manuscripts have proof of facts, their accomplishments, thoughts, work they need done, theories then on, that are essential for human development. These guide the younger generations for ages and should be saved for each coming generations. This article provides a short define of preservation strategies adopted to protect the manuscripts. Preventive measures should be applied with caution and value effective manner.