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This paper deals with the scientometric analysis of the global literature on Hydroxychloroquine as indexed in SCOPUS database from its first publication in 1946 to 2020. The objective of the study was to perform a scientometric analysis of Hydroxychloroquine publications. The study analyzed 25,163 publications which were contributed by 88,834 individual authors affiliated to 159 countries. The results showed momentum in the research publications during the 1980s and accelerated immediately from the beginning of the 21st century. It was observed a fluctuating trend for the Annual Growth Rate and CAGR recorded to 0.129635. The Relative Growth Rate recorded between 0.04 and 0.56 for different years. The Degree of Collaboration (DC) noted was 0.88 and 5.27 Collaboration Index (CI). The Journal of Rheumatology was the most preferred journal with 864 publications; Didier A. Raoult was the most productive author in Hydroxychloroquine (HCQ) research. The AP-HP Assistance Publique - Hopitaux de Paris, France was the top productive institution globally, and the USA was the most productive country in terms of the number of publications.