The main goal of this paper was to investigate the university students’ readiness for E-learning during the Covid-19 Pandemic. The rationale was to explore students’ readiness for the various E-learning platforms, examine the challenges faced by students in the use of the E-learning platforms (module) during Covid-19 Pandemic and also investigate the benefits of the use of the E-learning platforms. This study adopted a survey research design. From the 2019/2020 academic year of the University of Health and Allied Sciences, 345 students were selected by convenient sampling method. Their readiness for E-learning during the Covid-19 pandemic was assessed by a self-developed questionnaire. Data analysis was done using descriptive statistics. The study revealed that more than half (62.9%) of the students were not ready for the use of e-learning platforms with a level of study associated with readiness even though 91.6% of the participants had basic computer skills before the pandemic, 36.5% had prior experience with the use of E-learning platforms before COVID-19 Pandemic.