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The study focused on authorship pattern and collaboration in colorectal cancer research output as reflected in the web of science database for the period 2010-2017. Using various scientometrics approaches, the study presents co-authorship and collaborative patterns for different countries, institutions, and authors. We find multi and mega-author contributions which are increasing and dominate the CRC research. In the case of collaborative patterns, we found domestic collaboration which dominates the CRC research compared to international collaborations. Institution wise we find mostly domestic inter-institutional collaboration. Country pair-wise collaboration pattern shows that the US is the most preferred country for collaborations and the author-wise collaborative pattern in CRC research shows that the collaboration of domestic or local inter-institutional collaboration between the authors and highest possible combinations.