Endocrine and metabolic diseases are among the the most common contemporary human afflictions particularly in the United States and other developing countries like India and Srilanka. Hypothyroidism is due to the under activity of thyroid gland and results from its failure to secrete sufficient hormones into the blood stream. Hypothyroidism is a condition that reflects decreased concentrations of thyroid hormones due to any cause. This paper attempts to analyse management of hypothyroidism as reflected in publication output covered by Web of Science online database during 2018-2020 USA advanced with 156 (23.5 %) Articles and it occupies the first place in the European Continent. Italy, UK, China and France contributed nearly 100 Articles in this field. The challenge is how to best approach to increase the knowledge level thereby managing and preventing hypothyroidism.