The present research study is a snapshot of the influence and use of e-resources by the patrons of Engineering and Medical Colleges in the state of Goa. Living in the digital era, e-resources are increasingly important to all aspects of education from learning to teaching. The study aims at exploring the boundless influence of e- resources on the patrons, the use and needs and also the availability of e-resources in the libraries of medical and engineering colleges in Goa. The data for the study is gathered from 960 users which comprised of students and faculty. The exploration discovered that the use of e- resources in these two fields are increasing. E-resources provide incredible benefits and have a boundless influence over the minds of the patrons. It is also ascertained that there are a number of areas of good practices and innovative utilization of e-Resources for teaching and learning. The study suggested that Librarians have to take information literacy programs for users at regular intervals to develop searching capabilities of the patrons. The study proved that majority of the patrons (89%) is aware of the various types of E-Resources available in their field. The study proved that 85% of the patrons are extremely satisfied using e-resources in engineering and medicine discipline.