The present study aimed at finding out the research output of Issues in Science and Technology Librarianship (ISTL) during the period 2010-2020 through the scientometric analysis technique. For the analysis of the study, a total no of 35 issues of "ISTL Journal" published during the year 2010 to 2020 have been taken up for evaluation. After deep analysis, it is found that most of the articles in 130(42%) of the journals are Referred Articles (RA). In the journal, during the period a maximum number of 30(13.4%) articles were published in 2010 followed by 2015 and 2011. The degree of collaboration in ISTL publication is highest in the year 2020 with a mean value of 0.8 followed by a mean value of 0.76 in the year 2016. The average author per paper is highest (2.77) in the year 2019 followed by 2020 with 2.60 and 2.13 in 2012. The subject 'Information Literacy' has covered the highest number of 35(16%) articles followed by 'Science and Technology Resources on the Internet with 31(14%) and 'E-Resources' with 28(13%) articles.