Multidisciplinary collaboration is the hallmark of research in 21st century. Several academic disciplines or professional specialisations can now come together in an approach to solve a problem. Nowadays, most research projects are multifaceted and multidisciplinary, necessitating diverse and various set of expertise, knowledge, and backgrounds to bring about accomplishments. Digital humanity is a typical example of 21st-century multidisciplinary collaboration. Experts and scholars come together to research case studies and knowledge of various fields of study are employed to achieve a common goal. The approach to multidisciplinary collaboration is evident in all fields such as health and medical practices, financial forensics, criminal investigations, and also in libraries, information centres, archives as well as in museums. Emerging technology has made it possible for experts and scholars from different fields around the world to collaborate on projects and researches without being at the same location. Multidisciplinary collaboration results in the development of global best practices. This paper discusses the functions of multidisciplinary collaboration across disciplines, its impacts, and the opportunities. Conclusions was made on the application in modern libraries and how multidisciplinary collaboration can help achieve library goals and objectives as well as better serve their user community.