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Human Immunodeficiency Virus (HIV) has remained a social problem owing to the unavailability of a cure for the disease. Scholars have identified preventive behaviour as a remedy for the disease. Preventive behaviour is influenced by the information-seeking behaviour of individuals. This paper provides insight into people's health information-seeking behaviour concerning HIV prevention and implications for school-driven HIV prevention programmes. This was deemed necessary to encourage schools to brace up prevention efforts and foster understanding of what information students seek and how they seek such information particularly in this era of information and communication technology as this is very important for HIV prevention. Also, fostering understanding of students’ health information-seeking behaviour could be instrumental to schools in creating programmes for fostering students’ health behaviour change in respect of HIV. Previous studies reviewed in this paper regarding health information-seeking behaviour of people focused on people living with HIV, college students, Facebook users, university students among others.