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The study investigated the influence of use of mobile learning applications on academic engagement of Library and Information Science students in universities in South-West, Nigeria. The study adopted survey research design and questionnaire was used for data collection. One hundred and ninety-nine (199) copies of the questionnaire were administered out of which 184 copies were retrieved and fit for data analysis resulting in a 93% response rate. Analysis was done using SPSS version 23, percentages, mean, and standard deviation were used to analyse research questions and regression for the hypothesis which was tested at 0.05 level of significance. The findings revealed that the level of academic engagement of students was high, the purpose of use of mobile learning apps was for academic activities but the level of use of mobile learning application was low. The study concluded that the use of mobile learning apps had the capability to predict academic engagement of students. It was recommended that National Universities Commission (NUC) should include the provision of digital infrastructure and the use of mobile learning apps as part of the criteria for accreditation of courses in universities.