Information security compliance implies that library personnel follow the rules, guidelines, and principles regarding information security and implement the security measures provided in the library to curb insecurity. Information security compliance ensures that information resources held within the library are protected from unauthorized access and preserved from risk of loss, damage and unwanted modification. However, available literature showed that there is low compliance with information security by library personnel in university libraries in Nigeria. This has impacted negatively on the information resources held by the library, especially the printed materials. This situation might have resulted from lack of awareness about information security. This study therefore, examined the influence of information security awareness on information security compliance in university libraries in South-West, Nigeria. Adopting a descriptive survey research design, Multi-Stage random technique was used to select 223 library personnel (professional and Para-professional librarians) in university libraries in South-West, Nigeria who serve as the respondents. Data were collected with the use of questionnaire. The result of the findings revealed that information security awareness (R2=0.3305,β = 0.363, t = 8.836, p<0.05) had positive and significant influence on information security compliance. Information security compliance among library personnel in university libraries is of low level and there is a low level Information security awareness among library personnel in university libraries. The study concluded that information security awareness is inevitable for information security compliance in university libraries in South-West, Nigeria. The study recommended that management of the libraries should promote awareness programs that will enable library personnel gain more knowledge about the implementation process and the importance of information security that will assist them solve information security breaches and increase their compliance with information security.