The study investigated issues relating to the availability, accessibility, extent of use, and major factors inhibiting the use of ICT tools among the registry staff of the University of Ibadan, Oyo State. Survey design was adopted. The population comprised 520 members of staff across the various sections of the Registry, out of which 260 (50%) respondents were sampled. A structured questionnaire and an interview schedule were used for data collection. Quantitative data were subjected to frequency distribution, while interview responses were transcribed and thematically analysed. Findings showed that a good number of basic ICT tools such as desktop computers, printers, e-mail services, word processors, spreadsheets and presentation software are available to the registry staff for official work in the University, although some of them require upgrade. The available ICT tools are easily accessible to the registry staff for official work, and a high use of the ICT tools was revealed. The major challenges facing the registry staff in their use of ICT tools include inadequacy of ICT tools and consumables, obsolescence of ICT tools, lack of regular maintenance of ICT tools, unreliable internet access, unstable power supply, lack of technical assistance with ICT use, inadequate training, among others. Based on the findings, recommendations are made.