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Knowledge management is described as a systematic act of identifying, capturing, and disseminating information and knowledge so that individuals can utilize it to develop, complete, and improve knowledge. As such, knowledge management is viewed as both a concept and a practice and concept. Most firms are finding that knowledge management is a crucial instrument for preserving their reputation and standing in the global marketplace. This paper therefore aims to explore knowledge management among health professionals. Using the PRISMA approach, a systematic search was conducted on PUBMED and Google Scholar databases. The eligibility criteria include both qualitative and quantitative studies on knowledge management practices among health professionals. Extraction of data was done on all the papers that met the inclusion criteria based on the objectives of the study. A total of 115 articles were identified, of which 13 were selected for the review. Most of the publications examined emphasized knowledge sharing as a knowledge management practice. Knowledge sharing was through in-person interactions, social media, online forums, blogs, emails, etc. The respondents' methods for gathering and creating knowledge included using personal computers, tabs, laptops, mobile devices, bookmarks, etc. Knowledge acquisition and/or application was done through training programs, coaching, webinars, continuing medical education, and other avenues for health information. However, factors affecting knowledge sharing among health professionals include resource allocation, access to information sources, intrinsic motivation, ICT infrastructure, ICT training among others. The study's findings can be utilized as support for planning and implementing programs to enhance information sharing practices by health administrators, policy makers, health professionals, non-governmental organizations (NGOs), and researchers.