Date of this Version
University of Nebraska-Lincoln Spring 2017 Research Fair, Graduate Student Poster Session, April 5, 2017.
Atherosclerosis is a chronic disease that involves the lipid accumulation and inflammation of the arterial wall [1,2]. Despite great efforts,its pathophysiology has not been fully elucidated. Existent drugs can reduce its progression but there are no available drugs to prevent its complications [3,4]. Atherosclerosis remains the leading global cause of death.
The purpose of this work is to design and build a customized biochamber which can be used for the following studies:
•Study the pathophysiology of atherosclerosis in vitro & ex vivo
•Investigate the mechanisms of atherosclerotic plaque disruption
•Examine the direct effect of different anti-atherosclerotic drugs on lesions
•Use as a stenting simulation device for both research and educational purposes