Mechanical & Materials Engineering, Department of
ORCID IDs
http://orcid.org/0000-0002-7597-4358
http://orcid.org/0000-0003-2547-6438
http://orcid.org/0000-0002-2811-8030
http://orcid.org/0000-0002-7356-4814
http://orcid.org/0000-0003-0058-9954
Date of this Version
2017
Citation
The Author(s) 2017
Abstract
Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR studies. We demonstrate NMR spectroscopy of picoliter-volume solutions using a nanostructured diamond chip with dense, high-aspect-ratio nanogratings, enhancing the surface area by 15 times. The nanograting sidewalls are doped with nitrogen-vacancies located a few nanometers from the diamond surface to detect the NMR spectrum of roughly 1 pl of fluid lying within adjacent nanograting grooves. We perform 1H and 19F nuclear magnetic resonance spectroscopy at room temperature in magnetic fields below 50 mT. Using a solution of CsF in glycerol, we determine that 4 ± 2 × 1012 19F spins in a 1 pl volume can be detected with a signal-to-noise ratio of 3 in 1 s of integration. DOI: 10.1038/s41467-017-00266-4 OPEN 1
Included in
Mechanics of Materials Commons, Nanoscience and Nanotechnology Commons, Other Engineering Science and Materials Commons, Other Mechanical Engineering Commons
Comments
8: 188 | DOI: 10.1038/s41467-017-00266-4 | www.nature.com/naturecommunications