Plant Science Innovation, Center for


Date of this Version



Guodong Ren & Bin Yu (2012) Critical roles of RNA-binding proteins in miRNA biogenesis in Arabidopsis, RNA Biology, 9:12, 1424-1428. doi:10.4161/rna.22740


Copyright © 2012 Landes Bioscience. Published by Taylor & Francis Group. Used by permission.


MicroRNAs (miRNAs) are key regulators of gene expression and play critical roles in modulating metabolism, development and physiology in animals and plants. miRNA levels are transcriptionally and post-transcriptionally controlled for their proper function. Recent studies have shown that RNA-binding proteins play important roles in producing miRNAs by affecting the accurate and/or efficient processing of precursors of miRNAs. Many of these RNA-binding proteins also have roles in general RNA metabolism, indicating potential connections between miRNA biogenesis and other RNA metabolism. Here, we focus on the function of several RNA-binding proteins in miRNA biogenesis in Arabidopsis.