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Su JR, Brooks LC, Davis DW, et al. Congenital syphilis: trends in mortality and morbidity in the United States, 1999 through 2013. Am J Obstet Gynecol 2016;214:381.e1-9.


U.S. Government Work


BACKGROUND: Congenital syphilis (CS) results when an infected pregnant mother transmits syphilis to her unborn child prior to or at delivery. The severity of infection can range from a delivery at term without signs of infection to stillbirth or death after delivery.

OBJECTIVE: We sought to describe CS morbidity and mortality during 1999 through 2013.

STUDY DESIGN: National CS case data reported to Centers for Disease Control and Prevention during 1999 through 2013 were analyzed. Cases were classified as dead (stillbirths and deaths up to 12 months after delivery), morbid (cases with strong [physical, radiographic, and/or nonserologic laboratory] evidence of CS), and nonmorbid (cases with a normal physical examination reported, without strong evidence of infection). Annual rates of these cases were calculated. Cases were compared using selected maternal and infant criteria.

RESULTS: During 1999 through 2013, 6383 cases of CS were reported:

6.5% dead, 33.6% morbid, 53.9% nonmorbid, and 5.9% unknown

morbidity; 81.8% of dead cases were stillbirths. Rates of dead, morbid, and

nonmorbid cases all decreased over this time period, but the overall

proportions that were dead ormorbid cases did not significantly change. The

overall case fatality ratio during 1999 through 2013 was 6.5%. Among

cases of CS, maternal race/ethnicity was not associated with increased

morbidity or death, although most cases (83%) occurred among black or

Hispanic mothers. No or inadequate treatment for maternal syphilis, <10

prenatal visits, and maternal nontreponemal titer >1:8 increased the likelihood

of a dead case; risk of a dead case increased with maternal nontreponemal

titer (x2 for trend P < .001). Infants with CS born alive at <28

weeks’ gestation (relative risk, 107.4; P< .001) or born weighing<1500 g

(relative risk, 43.9; P < .001) were at greatly increased risk of death.

CONCLUSION: CS remains an important preventable cause of perinatal morbidity and mortality, with comparable case fatality ratios during 1999 through 2013 (6.5%) and 1992 through 1998 (6.4%). Detection and treatment of syphilis early during pregnancy remain crucial to reducing CS morbidity and mortality.