ChIPathlon: A competitive assessment for gene regulation tools.

Authors

Avi Knecht, University of Nebraska-LincolnFollow
Adam Caprez, University of Nebraska-LincolnFollow
Istvan Ladunga, University of Nebraska-LincolnFollow

ORCID IDs

Istvan Ladunga

Date of this Version

Spring 4-15-2016

Document Type

Presentation

Citation

UCARE presentation, University of Nebraska-Lincoln Research Fair, April 2016, Lincoln, NE.

Comments

Copyright © 2016 Avi Knecht, Adam Caprez, & Istvan Ladunga

Abstract

When gene regulation of the cell cycle malfunctions, it frequently causes cancer.

Adult, differentiated cells can be reprogrammed to induced pluripotent stem cell; which can then be reprogrammed to heart muscle, skin, etc, to repair damaged tissue (to limited extent in clinical practice).

ChIPathlon: Evaluate the performance of all transcription factor mapping (peak calling) methods. To this end, we will develop a scalable and easy to use super computing pipeline to stage data, compare many different peak calling and differential binding site tools, and store all results into a single database.