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The objective of this study was to test for genetic homogeneity among several discontinuous orchard pine vole populations, particularly between those that had been treated with endrin and those that had not. Endrin-resistant pine vole strains have been documented (Webb and Hors-fall 1967; Webb et a1. 1973), but have not been characterized genetically. Practically, this study was designed to determine if genetic differences existed among endrin-treated and non-treated orchard populations over two seasons of the year, by examining a few specific gene loci believed to be involved in endrin metabolism in small mammals.