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House mice (mus musculus) cause a variety of problems with livestock, feed, and structures. Researchers have yet to discover an insulative material that is not susceptible to house mouse damage. In this study, house mice caused significant (P < 0.01) increases in the thermal conductance of 10.2-cm thick wall panels, insulated with cellotex, fiberglass, rockwool, styrofoam, and vermiculite. Mouse populations increased 3-to 4-fold inside the insulated panels during the 6-month study period.