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A commercial feedlot experiment was conducted using 1,807 heifers to evaluate the effects of Optaflexx fed in combination with MGA on finishing heifer performance. In heifers receiving MGA throughout the entire 126-143 day feeding period, feeding Optaflexx for the last 31-38 days increased ADG and hot carcass weight compared to heifers fed MGA but not Optaflexx. Heifers fed MGA and Optaflexx had increased DMI, improved feed efficiency and increased final live weight. Carcass quality measurements were not influenced by treatment.