Animal Science Department


Date of this Version

January 2006


Published in 2006 Nebraska Beef Cattle Report. Copyright © 2005 The Board of Regents of the University of Nebraska.
Available online at


We identified 32 compounds that inhibit 13 to 100% of the methane produced by in vitro cultures of rumen fluid and have the potential to inhibit enteric methanogenesis in ruminant animals. The compounds are analogous to a substrate in the methane biosynthesis pathway, and may inhibit methane production yet not affect other organisms in the rumen.