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The MSE feed product contains multiple enzymes plus four strains of bacteria, two strains of yeast and three strains of fungi. The bacteria were three Lactobacillus acidophilus cultures and one strain of Bacillus subtilis; the yeasts were three strains of Saccharomyces cerevisiae; and the fungi were two strains of Aspergillus oryzae and one of Aspergillus niger. Potential benefits for feeding MSE to finishing beef cattle could be improvement in daily gain and fee utilization. Thus a feedlot trial was designed to compare MSE to an ionophore-antibiotic combination often fed to finishing cattle on a high grain diet to improve feed utilization and control the percentage of abscessed livers at slaughter.