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Cows were treated with two progestin concentrations to develop ovulatory follicles exposed to different hormone environments. Cows were assigned to Control Group receiving a CIDR for 7 days (4-6 ng/ml of progestin), or to MGA-14 Group receiving 5mg/head/day of MGA for 14 days (< 1 ng of progestin). Our hypothesis was that the MGA-14 treatment would develop larger, persistent follicles with less granulosa cells per follicle volume and may have altered gene expression profiles in oocytes and granulosa cells. Cows in the MGA-14 treatment had larger follicles and less granulosa cells per volume than controls, suggesting that their development mimicked persistent follicles and may be of poorer quality.