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A grain adaptation metabolism trial was conducted to compare wet corn gluten feed (WCGF, Sweet Bran®, Cargill) to wet distillers grains with solubles (WDGS). In both strategies, co-products were fed at decreasing levels (87.5% to 35% of DM). The WCGF step-up strategy resulted in greater DMI than WDGS for cattle fed steps 1, 2, and 3. The average of ruminal pH was lower for WDGS with steps 2 and 3 compared to WCGF. No differences in H2S between treatments were observed. Both WCGF and WDGS adaptation strategies resulted in safe ruminal pH, DMI, and H2S, even when S levels were high.