Stress-triggered Activation of the Metalloprotease Oma1 Involves Its C-terminal Region and Is Important for Mitochondrial Stress Protection in Yeast

Authors

Iryna Bohovych, University of Nebraska- LincolnFollow
Garrett Donaldson, University of Nebraska- Lincoln
Sara Christianson, University of Nebraska-Lincoln
Nataliya Zahayko, University of Nebraska-Lincoln
Oleh Khalimonchuk, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2014

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 19, pp. 13259–13272, May 9, 2014

DOI 10.1074/jbc.M113.542910

Comments

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: Oma1 is a conserved membrane-bound protease that forms a high molecular mass complex.

Results: Oma1 activity is induced by stress stimuli and required for survival. The activation is linked to changes in Oma1 oligomer stability and involves its C-terminal region.

Conclusion: Oma1 function is activated by mitochondrial stress and is important for stress tolerance.

Significance: Novel insights into Oma1 function and a potential stress activation mechanism are provided.