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2024

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Multifaceted roles of Meg3 in cellular senescence and atherosclerosis, Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Vijaya Bhaskar Baki, Matthew Moran, Huabo Su, and Xinghui Sun

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Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment, Satchal K. Erramilli, Pawel K. Dominik, Chinemerem P. Ogbu, Anthony A. Kossiakoff, and Alex J. J.

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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth, Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, and Jens Nielsen

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Augusta: From RNA-Seq to gene regulatory networks and Boolean models, Jana Musilova, Zdenek Vafek, Bhanwar Lal Puniya, Ralf Zimmer, Tomáš Helikar, and Karel Sedlar

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descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques, Kohei Otomo, Takaki Omura, Yuki Nozawa, Steven J. Edwards, Yukihiko Sato, Yuri Saito, Shigehiro Yagishita, Hitoshi Uchida, Yuki Watakabe, Kiyotada Naitou, Rin Yanai, Naruhiko Sahara, Satoshi Takagi, Ryohei Katayama, Yusuke Iwata, Toshiro Shiokawa, Yoku Hayakawa, Kensuke Otsuka, Haruko Watanabe-Takano, Yuka Haneda, Shigetomo Fukuhara, Miku Fujiwara, Takenobu Nii, Chikara Meno, Naoki Takeshita, Kenta Yashiro, Juan Marcelo Rosales Rocabado, Masaru Kaku, Tatsuya Yamada, Yumiko Oishi, Hiroyuki Koike, Yinglan Cheng, Keisuke Sekine, Jun-ichiro Koga, Kaori Sugiyama, Kenichi Kimura, Fuyuki Karube, Hyeree Kim, Ichiro Manabe, Tomomi Nemoto, Kazuki Tainaka, Akinobu Hamada, Hjalmar Brismar, and Etsuo A. Susaki

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Perspectives on computational modeling of biological systems and the significance of the SysMod community, Bhanwar Lal Puniya, Meghna Verma, Chiara Damiani, Shaimaa Bakr, and Andreas Dräger

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Vitamin E biofortification: enhancement of seed tocopherol concentrations by altered chlorophyll metabolism, Ping Qin, Peng Chen, Yuanwei Zhou, Wei Zhang, Yunyun Zhang, Jingjing Xu, Lu Gan, Yingnan Liu, Jill Romer, Peter Dörmann, Edgar B. Cahoon, and Chunyu Zhang

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Chromosome‑level assembly and analysis of Camelina neglecta: a novel diploid model for Camelina biotechnology research, Shuo Wang, Rostislav Y. Blume, Zhi‑Wei Zhou, Shaoping Lu, Tara J. Nazarenus, Yaroslav B. Blume, Weibo Xie, Edgar B. Cahoon, Ling‑Ling Chen, and Liang Guo

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Emerging Roles of Cullin-RING Ubiquitin Ligases in Cardiac Development, Josue Zambrano-Carrasco, Jianqiu Zou, Wenjuan Wang, Xinghui Sun, Jie Li, and Huabo Su

2023

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Plastic recognition and electrogenic uniport translocation of 1st-, 2nd-, and 3rd-row transition and post-transition metals by primary-active transmembrane P1B-2-type ATPase pumps, Sameera S. Abeyrathna, Nisansala S. Abeyrathna, Priyanka Basak, Gordon W. Irvine, LiMei Zhang, and Gabriele Meloni

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A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery, Sara Sadat Aghamiri, Bhanwar Lal Puniya, Rada Amin, and Tomáš Helikar

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Genome-wide investigation of SnRK2 gene family in two jute species: Corchorus olitorius and Corchorus capsularis, Borhan Ahmed, Fakhrul Hasan, Anika Tabassum, Rasel Ahmed, Rajnee Hassan, Ruhul Amin, and Mobashwer Alam

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Genome‑wide investigation of SnRK2 gene family in two jute species: Corchorus olitorius and Corchorus capsularis, Borhan Ahmed, Fakhrul Hasan, Anika Tabassum, Rasel Ahmed, Rajnee Hassan, Ruhul Amin, and Mobashwer Alam

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Oligogalactolipid production during cold challenge is conserved in early diverging lineages, Allison C. Barnes, Jennifer L. Myers, Samantha M. Surber, Zhikai Liang, Jeffrey P. Mower, James Schnable, and Rebecca Roston

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Editorial: Rising stars in microbial physiology and metabolism: 2022, Nicole R. Buan and Ulrike Kappler

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Hematopoietic stem cells and betaherpesvirus latency, Lindsey B. Crawford

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Functional Impact of a Cancer-Related Variant in Human Δ1‑Pyrroline-5-Carboxylate Reductase 1, Oseeyi I. Daudu, Kaylen R. Meeks, Lu Zhang, Javier Seravalli, John J. Tanner, and Donald F. Becker

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Editorial: Structure and function of chloroplasts, Volume III, Hongbo Gao, Alistair J. McCormick, Rebecca Roston, and Yan Lu

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Changes in lipid profiles of epileptic mouse model, Alicia Johnson, Ryan A. Grove, Deepak Madhavan, Cory Honsinger Thomas Boone, Camila Pereira Braga, Hannah Kyllo, Kaeli Samson, Timothy Simeone, Tomáš Helikar, Corrine K. Hanson, and Jiri Adamec

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Cellular Zinc Deficiency Impairs Heme Biosynthesis in Developing Erythroid Progenitors, Juyoung Kim, Jaekwon Lee, and Moon-Suhn Ryu

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Cobalt-sulfur coordination chemistry drives B12 loading onto methionine synthase, Romila Mascarenhas, Arkajit Guha, Zhu Li, Markus Ruetz, Sojin An, Javier Seravalli, and Ruma Banerjee

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Chloroquine and cytosolic galectins affect endosomal escape of antisense oligonucleotides after Stabilin-mediated endocytosis, Ekta Pandey and Ed Harris

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Advancements in computational modelling of biological systems: seventh annual SysMod meeting, Bhanwar Lal Puniya and Andreas Dräger

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The effects of exogenously applied antioxidants on plant growth and resilience, Aline Rodrigues de Queiroz, Connor Hines, Jeremy Brown, Seema Sahay, Jithesh Vijayan, Julie M. Stone, Nate Bickford, Melissa Wuellner, Katarzyna Glowacka, Nicole R. Buan, and Rebecca Roston

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Genetic control of photoprotection and photosystem II operating efficiency in plants, Seema Sahay, Marcin Grzybowski, James Schnable, and Katarzyna Głowacka

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Supplementation of Sulfide or Acetate and 2-Mercaptoethane Sulfonate Restores Growth of the Methanosarcina acetivorans ΔhdrABC Deletion Mutant during Methylotrophic Methanogenesis, Alicia M. Salvi, Niaz Bahar Chowdhury, Rajib Saha, and Nicole R. Buan

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Putrescine Detected in Strains of Staphylococcus aureus, Javier Seravalli and Frank Portugal

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Factors Influencing Instructors’ Adoption and Continued Use of Computing Science Technologies: A Case Study in the Context of Cell Collective, Changsoo Song, Resa M. Helikar, Wendy Smith, and Tomáš Helikar

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Factors Influencing Instructors’ Adoption and Continued Use of Computing Science Technologies: A Case Study in the Context of Cell Collective, Changsoo Song, Resa M. Helikar, Wendy M. Smith, and Tomáš Helikar

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Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling, Raju Lama Tamang, Balawant Kumar, Sagar M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. Becker, Dundy Kiran Bastola, Punita Dhawan, and Amar B. Singh

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Type IV Pilus-Mediated Inhibition of Acinetobacter baumannii Biofilm Formation by Phenothiazine Compounds, Nam Vo, Benjamin S. Sidner, Yafan Yu, and Kurt H. Piepenbrink

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Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR‑143/145, Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris, and Qiaozhu Su

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A novel method of rapid detection for heavy metal copper ion via a specific copper chelator bathocuproinedisulfonic acid disodium salt, Yali Wang, Tinglin Ma, Joseph Brake, Zhaoyue Sun, Jiayu Huang, Jing Li, and Xiaobin Wu

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Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis, Tao Wan, Magdaléna Horová, Vimmy Khetrapal, Shanren Li, Camden Jones, Andrew Schacht, Xinghui Sun, and LiMei Zhang

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A Facile Strategy for the Fabrication of Cell-Laden Porous Alginate Hydrogels based on Two-Phase Aqueous Emulsions, Wen Xue, Donghee Lee, Yunfan Kong, Mitchell Kuss, Ying Huang, Taesung Kim, Soonkyu Chung, Andrew T. Dudley, Seung-Hyun Ro, and Bin Duan

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Endogenous L- to D-amino acid residue isomerization modulates selectivity between distinct neuropeptide receptor family members, Baba M. Yussif, Cole V. Blasing, and James W. Checco

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Conformal Electrodeposition of Antimicrobial Hydrogels Formed by Self-Assembled Peptide Amphiphiles, Gervasio Zaldivar, Jiachen Feng, Leonardo Lizarraga, Yafan Yu, Luana de Campos, Kelly Mari Pires de Oliveira, Kurt Piepenbrink, Martin Conda-Sheridan, and Mario Tagliazucchi

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BOLA3 and NFU1 Link Mitoribosome Iron–Sulfur Cluster Assembly to Multiple Mitochondrial Dysfunctions Syndrome, Hui Zhong, Alexandre Janer, Oleh Khalimonchuk, Hana Antonicka, Eric A. Shoubridge, and Antoni Barrientos

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BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome, Hui Zhong, Alexandre Janer, Oleh Khalimonchuk, Hana Antonicka, Eric Shoubridge, and Antoni Barrientos

2022

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Guard-cell-targeted overexpression of Arabidopsis Hexokinase 1 can improve water use efficiency in field-grown tobacco plants, Liana G. Acevedo-Siaca, Katarzyna Glowacka, Steven M. Driever, Coralie E. Salesse-Smith, Nitsan Lugassi, David Granot, Stephen P. Long, and Johannes Kromdijk

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Sesamum indicum diet prevents hyperlipidemia in experimental rats, Muinat M. Adeyanju, Idris A. Saheed, Oluwaseun I. Oyelekan, Taiwo A. Dele-Osibanjo, Ayodeji A. Adelegan, Adekunle J. Raimi, Samuel O. Olalekan, Olugbenga S. Alabi, and Khadijat M. Alli

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In Silico Identification of Potential Inhibitors of the SARS‑CoV‑2 Nucleocapsid Through Molecular Docking‑Based Drug Repurposing, Rukhsar Afreen, Saleem Iqbal, Ab Rauf Shah, Heena Afreen, Maitreyi College, and Mohd. Shkir

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Functional foods: promising therapeutics for Nigerian Children with sickle cell diseases, Oladeji John Alabi, Fikayo Noah Adegboyega, Dolapo Samuel Olawoyin, and Oluwakemi Arinola Babatunde

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The follicular lymphoma epigenome regulates its microenvironment, Rada Amin and Mounia S. Braza

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ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function, Desiree M. Barron, Adam R. Fenton, Sara Saez-Atienzar, Anthony Giampetruzzi, Aparna Sreeram, Shankaracharya, Pamela J. Keagle, Victoria R. Doocy, Nathan J. Smith, Eric W. Danielson, Megan Andresano, Mary C. McCormack, Jaqueline Garcia, Valérie Bercier, Ludo Van Den Bosch, Jonathan R. Brent, Claudia Fallini, Brian J. Traynor, Erica L.F. Holzbaur, and John E. Landers

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Insights into the biotechnology potential of Methanosarcina, Sean Carr and Nicole R. Buan

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Metabolic Synergy between Human Symbionts Bacteroides and Methanobrevibacter, Jennie L. Catlett, Sean Carr, Mikaela Cashman, Megan D. Smith, Mary Walter, Zahmeeth Sakkaff, Christine A. Kelley, Massimiliano Pierobon, Myra B. Cohen, and Nicole R. Buan

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Altered collective mitochondrial dynamics in the Arabidopsis msh1 mutant compromising organelle DNA maintenance, Joanna M. Chustecki, Ross D. Etherington, Daniel J. Gibbs, and Iain G. Johnston

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Fish Oil Intake During Gestation and Lactation Attenuated STZ-Induced Diabetes inMale Offspring via Activation of Brown Fat and Modulating Oxylipin Profile, Rong Fan, Shalom Thomas, Mikyoung You, Zhuoheng Li, Brandt Bessell, Bhanwar Lal Puniya, Tomáš Helikar, Zhenhua Liu, and Soonkyu Chung

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Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity, Belén Fernández, Vinita G. Chittoor-Vinod, Jillian H. Kluss, Kaela Kelly, Nicole Bryant, An Phu Tran Nguyen, Syed A. Bukhari, Nathan J. Smith, Antonio Jesús Lara Ordóñez, Elena Fdez, Marie-Christine Chartier-Harlin, Thomas J. Montine, Mark A. Wilson, Darren J. Moore, Andrew B. West, Mark R. Cookson, R. Jeremy Nichols, and Sabine Hilfiker

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NCOA4 Regulates Iron Recycling and Responds to Hepcidin Activity and Lipopolysaccharide in Macrophages, Cole A. Guggisberg, Juyoung Kim, Jaekwon Lee, Xiaoli Chen, and Moon-Suhn Ryu

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Metabolite Damage and Damage Control in a Minimal Genome, Drago Haas, Antje M. Thamm, Jiayi Sun, Lili Huang, Lijie Sun, Guillaume A.W. Beaudoin, Kim S. Wise, Claudia Lerma-Ortiz, Steven D. Bruner, Marian Breuer, Zaida Luthey-Schulten, Jiusheng Lin, Mark A. Wilson, Greg Brown, Alexander F. Yakunin, Inna Kurilyak, Jacob Folz, Oliver Fiehn, John I. Glass, Andrew D. Hanson, Christopher S. Henry, and Valérie de Crécy-Lagard

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HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2), Imam Abdulrahman Bin Faisal University, Chengju Tian, Sean R. Bidasee, Zachary L. Venn, Evan Schroder, Nick Y. Palermo, Mohammad AlShabeeb, Benson J. Edagwa, Jason J. Payne, and Keshoer R. Bidasee

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Reduction of Stabilin-2 Contributes to a Protection Against AtherosclerosisStabilin, Yukako Kayashima1*,; Conner A. Clanton; Amanda M. Lewis; Xinghui Sun; Sylvia Hiller; Phillip Huynh; Jennifer Wilder; John Hagaman; Feng Li; Nobuyo Maeda-Smithies; and Edward N. Harris

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Reduction of Stabilin-2 Contributes to a Protection Against Atherosclerosis, Yukako Kayashima, Connor A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, and Ed Harris

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Editorial: Mitochondria, metabolism and cardiovascular diseases, Jun-ichiro Koga, Xinghui Sun, and Masuko Ushio-Fukai

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Building digital twins of the human immune system: toward a roadmap, Reinhard Laubenbacher, Anna Niarakis, Tomas Helikar, G. An, B. Shapiro, R. S. Malik-Sheriff, T. J. Sego, P. Macklin, and J. A. Glazier

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A glass bead semi‑hydroponic system for intact maize root exudate analysis and phenotyping, Martha G. Lopez-Guerrero, Peng Wang, Felicia Phares4, Daniel P. Schachtman, Sophie Alvarez, and Karin van Dijk

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DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons, Melissa Conti Mazza, Sarah C. Shuck, Jiusheng Lin, Michael Moxley, John Termini, Mark R. Cookson, and Mark A. Wilson

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Addressing barriers in comprehensiveness, accessibility, reusability, interoperability and reproducibility of computational models in systems biology, Anna Niarakis, Dagmar Waltemath, James Glazier, Falk Schreiber, Sarah M. Keating, David Nickerson, Claudine Chaouiya, Anne Siegel, Vincent Noël, Henning Hermjakob, Tomáš Helikar, Sylvain Soliman, and Laurence Calzone

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Coordination of metal center biogenesis in human cytochrome c oxidase, Eva Nývltová, Jonathan Dietz, Javier Seravalli, Oleh Khalimonchuk, and Antoni Barrientos

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Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology, Chinemerem P. Ogbu, Sourav Roy, and Alex J. Vecchio

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Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes, Benjamin J. Orlando, Pawel K. Dominik, Sourav Roy, Chinemerem P. Ogbu, Satchal K. Erramilli, Anthony A. Kossiakoff, and Alex J. Vecchio

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Role of Specialized Pro-resolving Mediators in Reducing Neuroinflammation in Neurodegenerative Disorders, Jana Ponce, Arzu ulu, Corrine Hanson, Erin Cameron-Smith, Jenna Wuebker, John Bertoni, Alfred Fisher, Ka-Chun Siu, Vivien Marmelat, Jiri Adamec, and Danish Bhatti

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Feedlot diets containing different starch levels and additives change the cecal proteome involved in cattle’s energy metabolism and inflammatory response, Leone Campos Rocha, Andrey Sávio de Almeida Assunção, Renata Aparecida Martins, Victor Valério de Carvalho, Alexandre Perdigão2, Marília Afonso Rabelo Buzalaf, Jiri Adamec, Camila Pereira Braga, Danilo Domingues Millen, José Cavalcante Souza Vieira, and Pedro de Magalhães Padilha

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Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile, Leslie A. Ronish, Ben Sidner, Yafan Yu, and Kurt H. Piepenbrink

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Variation on a theme: the structures and biosynthesis of specialized fatty acid natural products in plants, Samuel Scott, Edgar B. Cahoon, and Lucas Busta

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A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures, Sushil K. Shakyawar, Nitish K. Mishra, Neetha N. Vellichirammal, Lynnette Cary, Tomáš Helikar, Robert Powers, Rebecca E. Oberley-Deegan, David B. Berkowitz, Kenneth W. Bayles, Vijay K. Singh, and Chittibabu Guda

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Reproducibility of protein x-ray diffuse scattering and potential utility for modeling atomic displacement parameters, Zhen Su, Medhanjali Dasgupta, Frédéric Poitevin, Irimpan I. Mathews, Henry van den Bedem, Michael E. Wall, Chun Hong Yoon, and Mark A. Wilson

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Editorial: Function and formation of mitochondrial metalloproteome, Michał Wasilewski, Vishal M. Gohil, and Oleh Khalimonchuk

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Loss of Num1-mediated cortical dynein anchoring negatively impacts respiratory growth, Antoineen J. White, Clare S. Harper, Erica M. Rosario, Jonathan V. Dietz, Hannah G. Addis, Jennifer L. Fox, Oleh Khalimonchuk, and Laura L. Lackner

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Endothelial cell-specific deletion of a microRNA accelerates atherosclerosis, Dafeng Yang, Stefan Haemmig, Jingshu Chen, Michael McCoy, Henry S. Cheng, Haoyang Zhou, Daniel Pérez-Cremades, Xiao Cheng, Xinghui Sun, Jorge Haneo-Mejia, Shamsudheen K. Vellarikkal, Rajat M. Gupta, Victor Barrera, and Mark W. Feinberg

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Arginine Catabolism and Polyamine Biosynthesis Pathway Disparities Within Francisella tularensis Subpopulations, Yinshi Yue, Bhanwar Lal Puniya, Tomáš Helikar, Benjamin Girardo, Steven H. Hinrichs, and Marilyn A. Larson

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Two heads are better than one: current landscape of integrating QSP and machine learning, Tongli Zhang, Ioannis P. Androulakis, Peter Bonate, Limei Cheng, Tomáš Helikar, Jaimit Parikh, Christopher Rackauckas, Kalyanasundaram Subramanian, and Carolyn R. Cho

2021

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Recent applications of quantitative systems pharmacology and machine learning models across diseases, Sara Sadat Aghamiri1, Rada Amin, and Tomáš Helikar

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Anaerobic Production of Isoprene by Engineered Methanosarcina Species Archaea, Jared T. Aldridge, Sean Carr, Karrie A. Weber, and Nicole R. Buan

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LIQUID AND SEMISOLID LUBRICANT COMPOSITIONS , METHODS OF MAKING , AND USES THEREOF, Diana Berman, Kent Dean Chapman, Tervor Bradley Romsdahl, Edgar Benjamin Cahoon, Robert Earl Minto, and Chunyu Zhang

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Teaching Metabolism in Upper-Division Undergraduate Biochemistry Courses using Online Computational Systems and Dynamical Models Improves Student Performance, Christine S. Booth, Changsoo Song, Michelle E. Howell, Achilles Rasquinha, Aleš Saska, Resa M. Helikar, Sharmin M. Sikich, Brain A. Couch, Karin van Dijk, Rebecca Roston, and Tomáš Helikar

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Purification and Initial Biochemical Characterization of ATP:Cob(I)alamin Adenosyltransferase (EutT) Enzyme of Salmonella enterica, Nicole R. Buan and Jorge C. Escalante-Semerena

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A co-opted steroid synthesis gene, maintained in sorghum but not maize, is associated with a divergence in leaf wax chemistry, Lucas Busta, Elizabeth Schmitz, Dylan K. Kosma, James Schnable, and Edgar B. Cahoon

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Stabilin receptors clear LPS and control systemic inflammation, Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V.S. Rajaram, Edward N. Harris, and Latha P. Ganesan

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Isoprene Production from Municipal Wastewater Biosolids by Engineered Archaeon Methanosarcina acetivorans, Sean Carr, Jared Aldridge, and Nicole R. Buan

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Isoprene Production from Municipal Wastewater Biosolids by Engineered Archaeon Methanosarcina acetivorans, Sean Carr, Jared Aldridge, and Nicole R. Buan

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Genetic Engineering of Lesquerella with Increased Ricinoleic Acid Content in Seed Oil, Grace Q. Chen, Kumiko Johnson, Tara J. Nazarenus, Grisel Ponciano, Eva Morales, and Edgar B. Cahoon

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Genetic Engineering of Lesquerella with Increased Ricinoleic Acid Content in Seed Oil, Grace Q. Chen, Kumiko Johnson, Tara J. Nazarenus, Grisel Ponciano, Eva Morales, and Edgar B. Cahoon

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Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity, Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L. Schlichte, Matthew C. Zimmerman, Oleh Khalimonchuk, Mark W. Feinberg, and Xinghui Sun

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Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity, Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L. Schlichte, Matthew C. Zimmerman, Oleh Khalimonchuk, Mark W. Feinberg, and Xinghui Sun

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A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection, Prasanta K. Dasg, Fadhel A. Alomar, Jesse L. Cox, JoEllyn McMillan, Bryan T. Hackfort, Edward Makarov, Brenda Morsey, Howard S. Fox, Howard E. Gendelman, Santhi Gorantla, and Keshore R. Bidasee

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Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond, Jonathan Dietz, Jennifer L. Fox, and Oleh Khalimonchuk

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Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase, Jonathan V. Dietz, Mathilda M. Willoughby, Robert B. Piel, Teresa A. Ross, Iryna Bohovych, Hannah G. Addis, Jennifer L. Fox, William N. Lanzilotta, Harry A. Dailey, James A. Wohlschlegel, Amit R. Reddi, Amy E. Medlock, and Oleh Khalimonchuk

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Generating Pennycress (Thlaspi arvense) Seed Triacylglycerols and Acetyl-Triacylglycerols Containing Medium-Chain Fatty Acids, Maliheh Esfahanian, Tara J. Nazarenus, Meghan M. Freund, Gary McIntosh, Winthrop B. Phippen, Mary E. Phippen, Timothy P. Durrett, Edgar B. Cahoon, and John C. Sedbrook

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The Need for Research-Grade Systems Modeling Technologies for Life Science Education, Tomáš Helikar

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Europium sulfide nanoprobes predict antiretroviral drug delivery into HIV-1 cell and tissue reservoirs, Jonathan Herskovitz, Mahmudul Hasan, Jatin Machhi, Insiya Mukadam, Brendan M. Ottemann, James R. Hilaire, Christopher Woldstad, JoEllyn McMillan, Yutong Liu, Javier Seravalli, Anandakumar Sarella, Howard E. Gendelman, and Bhavesh D. Kevadiya

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Reintegrating Biology through the Nexus of Energy, Information, and Matter, Kim L. Hoke, Sara L. Zimmer, Adam B. Roddy, Mary Jo Ondrechen, Craig E. Williamson, and Nicole R. Buan

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CRISPR/Cas9-Induced fad2 and rod1 Mutations Stacked With fae1 Confer High Oleic Acid Seed Oil in Pennycress (Thlaspi arvense L.), Brice A. Jarvis, Trevor B. Romsdahl, Michaela G. McGinn, Tara J. Nazarenus, Edgar B. Cahoon, Kent D. Chapman, and John C. Sedbrook

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Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis, Jung-Hwan Kim, Tsutomu Matsubara, Jaekwom Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J. Chang, Heejung Yang, Tomokazu Nagano, Kristopher W. Krausz, Sun Hee Yim, and Frank J. Gonzalez

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A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis, Scott Latimer, Shea A. Keene, Lauren R. Stutts, Antoine berger, Ann C. Bernert, Eric Soubeyrand, Janet D. Wright, Catherine F. Clarke, Anna K. Block, Thomas A. Colquhoun, Christian Elowsky, Alan C. Christensen, Mark A. Wilson, and Gilles J. Basset

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Highlighting membrane protein structure and function: A celebration of the Protein Data Bank, Fei Li, Pascal F. Egea, Alex J. Vecchio, Ignacio Asial, Meghna Gupta, Joana Paulino, Ruchika Bajaj, Miles Sasha Dickinson, Shelagh Fergunson-Miller, Brian C. Monk, and Robert M. Stroud

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Dynamic Evolution and Correlation between Metabolites and Microorganisms during Manufacturing Process and Storage of Fu Brick Tea, Jing Li, Ran Xu, Joseph Brake, Lizeng Cheng, Jie Wu, and Xiaobin Wu

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Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome, Robert Moore, Bhanwar Lal Puniya, Robert Powers, Chittibabu Guda, Kenneth W. Bayles, David Berkowitz, and Tomas Helikar