Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 21, pp. 13144–13156, May 22, 2015
Background: Hyal1 is a turnover enzyme for hyaluronan that accelerates metastatic cancer by increasing cell motility.
Results: Hyal1-overexpressing cells have a higher rate of endocytosis that impacts cargo internalization and recycling.
Conclusion: The higher rate of vesicle trafficking increases motility receptor function and nutrient uptake.
Significance: This novel mechanism implicates Hyal1 trafficking in multiple signaling events during tumor progression.