Date of this Version
The Journal of Biological Chemistry, VOL. 287, NO. 10, pp. 7289–7300, March 2, 2012
Background: Yeast lacking Coa2 are deficient in cytochrome c oxidase due to Cox1 degradation.
Results: Oma1 mediates Cox1 degradation in coa2∆ cells but not other mutants stalled in oxidase biogenesis.
Conclusion: Impaired hemylation of Cox1 in coa2∆ cells leads to misfolding and facile degradation by Oma1.
Significance: Oma1 functions in quality control of cytochrome oxidase assembly.