Identification of Trace Element-Containing Proteins in Genomic Databases

Authors

Vadim N. Gladyshev, University of Nebraska-LincolnFollow
Gregory V. Kryukov, University of Nebraska-Lincoln
Dmitri E. Fomenko, University of Nebraska-LincolnFollow
Dolph L. Hatfield, National Institutes of Health, Bethesda, MarylandFollow

Date of this Version

2004

Comments

Published in Annual Review of Nutrition 2004. 24:579–96; doi: 10.1146/annurev.nutr.24.012003.132241

Abstract

Development of bioinformatics tools provided researchers with the ability to identify full sets of trace element–containing proteins in organisms for which complete genomic sequences are available. Recently, independent bioinformatics methods were used to identify all, or almost all, genes encoding selenocysteine-containing proteins in human, mouse, and Drosophila genomes, characterizing entire selenoproteomes in these organisms. It also should be possible to search for entire sets of other trace element–associated proteins, such as metal-containing proteins, although methods for their identification are still in development.