Jay F. Storz
School of Biological Sciences
University of Nebraska
Lincoln, NE 68588

E-mail: jstorz2@unl.edu


The primary focus of my research is the genetic basis of adaptive evolutionary change. One of the main goals is to understand the role of selection in shaping patterns of adaptive genetic variation in natural populations. On a more macroevolutionary timescale, we are investigating the differential gain and loss of genes from homologous gene families as a source of functional variation among the genomes of different species. Research in my lab integrates molecular population genetics, molecular evolution, comparative genomics, and experimental studies of protein function.

Lab homepage: http://biosci-labs.unl.edu/storz/index.html

Complete list of publications with links to pdfs: http://biosci-labs.unl.edu/storz/publications.html

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2013

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Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin, Chandrasekhar Natarajan, Noriko Inoguchi, Roy E. Weber, Angela Fago, Hideaki Moriyama, and Jay F. Storz

2012

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Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice, Zachary A. Cheviron, Gwendolyn C. Bachman, Alex D. Connaty, and Jay F. Storz

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Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content, Jay F. Storz, Roy E. Weber, and Angela Fago

2011

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Differential Loss and Retention of Cytoglobin, Myoglobin, and Globin-E during the Radiation of Vertebrates, Federico G. Hoffmann, Juan C. Opazo, and Jay F. Storz

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Expression and Purification of Recombinant Hemoglobin in Escherichia coli, Chandrasekhar Natarajan, Xiaoben Jiang, Angela Fago, Roy E. Weber, Hideaki Moriyama, and Jay F. Storz

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Evolutionary Origins of Oxygen Sensing in Animals, Kalle T. Rytkönen and Jay F. Storz

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Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis, Jay F. Storz, Federico G. Hoffmann, Juan C. Opazo, Thomas J. Sanger, and Hideaki Moriyama

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Phylogenetic Diversification of the Globin Gene Superfamily in Chordates, Jay F. Storz, Juan C. Opazo, and Federico G. Hoffmann

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Experimental Approaches to Evaluate the Contributions of Candidate Protein-Coding Mutations to Phenotypic Evolution, Jay F. Storz and Anthony J. Zera

2010

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Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole, Kevin L. Campbell, Jay F. Storz, Anthony V. Signore, Hideaki Moriyama, Kenneth C. Catania, Alexander P. Payson, Joseph Bonaventura, Jörg Stetefeld, and Roy E. Weber

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Gene cooption and convergent evolution of oxygen transport hemoglobins in jawed and jawless vertebrates, Federico G. Hoffmann, Juan C. Opazo, and Jay F. Storz

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Lineage-Specific Patterns of Functional Diversification in the α- and β-Globin Gene Families of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz, Thomas A. Gorr, and Juan C. Opazo

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Structure and Reactivity of Hexacoordinate Hemoglobins, Smita Kakar, Federico G. Hoffmann, Jay F. Storz, Marian Fabian, and Mark S. Hargrove

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Genes for High Altitudes, Jay F. Storz

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Genetic differences in hemoglobin function between highland and lowland deer mice, Jay F. Storz, Amy M. Runck, Hideaki Moriyama, Roy E. Weber, and Angela Fago

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Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates, Jay F. Storz, Graham R. Scott, and Zachary A. Cheviron

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Integrating Evolutionary and Functional Approaches to Infer Adaptation at Specific Loci, Jay F. Storz and Christopher W. Wheat

2009

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Molecular evolution of cytochrome b in high- and low-altitude deer mice (genus Peromyscus), E. J. Gering, J. C. Opazo, and Jay F. Storz

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Origin and Ascendancy of a Chimeric Fusion Gene: The β/δ-Globin Gene of Paenungulate Mammals, Juan C. Opazo, Angela M. Sloan, Kevin L. Campbell, and Jay F. Storz

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Evolution of Duplicated β-Globin Genes and the Structural Basis of Hemoglobin Isoform Differentiation in Mus, Amy M. Runck, Hideaki Moriyama, and Jay F. Storz

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Gene Duplication and the Resolution of Adaptive Conflict, Jay F. Storz

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Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin, Jay F. Storz, Amy M. Runck, Stephen J. Sabatino, John K. Kelly, Nuno Ferrand, Hideaki Moriyama, Roy E. Weber, and Angela Fago

2008

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Evidence for contrasting modes of selection at interacting globin genes in the European rabbit (Oryctolagus cuniculus), R. Campos, Jay F. Storz, and N. Ferrand

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Molecular evolution of cytochrome b in high- and low-altitude deer mice (genus Peromyscus), E.J. Gering, J. C. Opazo, and Jay F. Storz

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Rapid Rates of Lineage-Specific Gene Duplication and Deletion in the α-Globin Gene Family, Federico G. Hoffmann, Juan C. Opazo, and Jay F. Storz

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New Genes Originated via Multiple Recombinational Pathways in the β-Globin Gene Family of Rodents, Frederico Hoffmann, Juan Opazo, and Jay F. Storz

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Genomic evidence for independent origins of β-like globin genes in monotremes and therian mammals, Juan C. Opazo, Federico G. Hoffmann, and Jay F. Storz

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Differential loss of embryonic globin genes during the radiation of placental mammals, Juan C. Opazo, Federico Hoffmann, and Jay F. Storz

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Adaptive Functional Divergence among Triplicated α-Globin Genes in Rodents, Jay F. Storz, Federico G. Hoffmann, Juan C. Opazo, and Hideaki Moriyama

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Effects of Spatially Varying Selection on Nucleotide Diversity and Linkage Disequilibrium: Insights From Deer Mouse Globin Genes, Jay F. Storz and John K. Kelly

2007

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The αD-Globin Gene Originated via Duplication of an Embryonic α-Like Globin Gene in the Ancestor of Tetrapod Vertebrates, Federico G. Hoffmann and Jay F. Storz

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HEMOGLOBIN FUNCTION AND PHYSIOLOGICAL ADAPTATION TO HYPOXIA IN HIGH-ALTITUDE MAMMALS, Jay F. Storz

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Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice, Jay F. Storz, Monica Baze, Jessica L. Waite, Federico G. Hoffmann, Juan C. Opazo, and Jack P. Hayes

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THE STUDY OF ADAPTATION AND SPECIATION IN THE GENOMIC ERA, Jay F. Storz and Hopi E. Hoekstra

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Supporting Information for "The Molecular Basis of High-Altitude Adaptation in Deer Mice", Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, and Michael W. Nachman

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The Molecular Basis of High-Altitude Adaptation in Deer Mice, Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, and Michael W. Nachman

2006

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Evolutionary Dynamics of the Short-Nosed Fruit Bat, Cynopterus sphinx (Pteropodidae): Inferences from the Spatial Scale of Genetic and Phenotypic Differentiation, Jay F. Storz, Hari R. Bhat, Johnson Balasingh, P. Thiruchenthil Nathan, and Thomas H. Kunz

2005

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Nonrandom dispersal and local adaptation, Jay F. Storz

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Using genome scans of DNA polymorphism to infer adaptive population divergence, Jay F. Storz

2004

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Estimation of genetically effective breeding numbers using a rejection algorithm approach, Uma Ramakrishnan, Jay F. Storz, Barbara L. Taylor, and Russell Lande

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Natural Selection Drives Altitudinal Divergence at the Albumin Locus in Deer Mice, Peromyscus Maniculatus, Jay F. Storz and Jean M. Dubach

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Genome Scans of DNA Variability in Humans Reveal Evidence for Selective Sweeps Outside of Africa, Jay F. Storz, Bret A. Payseur, and Michael W. Nachman

2003

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Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence from Interlocus Contrasts, Jay F. Storz and Michael W. Nachman

2002

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Contrasting Patterns of Divergence in Quantitative Traits and Neutral DNA Markers: Analysis of Clinal Variation, Jay F. Storz

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Testing for Genetic Evidence of Population Expansion and Contraction: An Empirical Analysis of Microsatellite DNA Variation Using a Hierarchical Bayesian Model, Jay F. Storz and Mark Beaumont

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Genetic Evidence for Long-Term Population Decline in a Savannah Dwelling Primate: Inferences from a Hierarchical Bayesian Model, Jay F. Storz, Mark A. Beaumont, and Susan C. Alberts

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Genetic Effective Size of a Wild Primate Population: Influence of Current and Historical Demography, Jay F. Storz, Uma Ramakrishnan, and Susan C. Alberts

2001

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Clinal variation in body size and sexual dimorphism in an Indian fruit bat, Cynopterus sphinx (Chiroptera: Pteropodidae), Jay F. Storz, J. Balasingh, Hari Bhat, P. Thiruchenthil Nathan, D. Paramanantha Swami Doss, A. Antony Prakash, and Thomas H. Kunz

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Genetic Consequences of Polygyny and Social Structure in an Indian Fruit Bat, Cynopterus sphinx. I. Inbreeding, Outbreeding, and Population Subdivision, Jay F. Storz, Hari Bhat, and Thomas Kunz

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Genetic Consequences of Polygyny and Social Structure in an Indian Fruit Bat, Cynopterus sphinx. II. Variance in Male Mating Success and Effective Population Size, Jay F. Storz, Hari Bhat, and Thomas H. Kunz

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Determinants of Effective Population Size for Loci with Different Modes of Inheritance, Jay F. Storz, U. Ramakrishnan, and S. C. Alberts

2000

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Variation at tri- and tetranucleotide repeat microsatellite loci in the fruit bat genus Cynopterus (Chiroptera: Pteropodidae), Jay F. Storz

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Dispersion and site fidelity in a tent-roosting population of the short-nosed fruit bat (Cynopterus sphinx) in southern India, Jay F. Storz, J. Balasingh, P. Thiruchenthil Nathan, K. Emmanuel, and Thomas H. Kunz

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Social structure of a polygynous tent-making bat, Cynopterus sphinx (Megachiroptera), Jay F. Storz, Hari Bhat, and Thomas H. Kunz

1999

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Genetic Consequences of Mammalian Social Structure, Jay F. Storz

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Cynopterus sphinx, Jay F. Storz and Thomas H. Kunz

1997

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Selective Feeding by Phyllostomid Fruit Bats in a Subtropical Montane Cloud Forest, David Herníndez-Conrique, Luis Iñiguez-Dávalos, and Jay F. Storz