Jay F. Storz
School of Biological Sciences
University of Nebraska
Lincoln, NE 68588

E-mail: jstorz2@unl.edu


The primary focus of my research is the genetic basis of adaptive evolutionary change. One of the main goals is to understand the role of selection in shaping patterns of adaptive genetic variation in natural populations. On a more macroevolutionary timescale, we are investigating the differential gain and loss of genes from homologous gene families as a source of functional variation among the genomes of different species. Research in my lab integrates molecular population genetics, molecular evolution, comparative genomics, and experimental studies of protein function.

Lab homepage: http://biosci-labs.unl.edu/storz/index.html

Complete list of publications with links to pdfs: http://biosci-labs.unl.edu/storz/publications.html

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2017

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Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobinoxygen affinity of high-altitude deer mice, Noriko Inoguchi, Nobuhiro Mizuno, Seiki Baba, Takashi Kumasaka, Chandrasekhar Natarajan, Jay F. Storz, and Hideaki Moriyama

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Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin, Amit Kumar, Chandrasekhar Natarajan, Hideaki Moriyama, Christopher C. Witt, Roy E. Weber, Angela Fago, and Jay F. Storz

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Rewiring metabolism under oxygen deprivation: Naked mole-rats evolved a means to cope with anoxia, Jay F. Storz and Grant B. McClelland

2016

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Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice, Birgitte Jensen and Jay F. Storz

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Predictable convergence in hemoglobin function has unpredictable molecular underpinnings, Chandrasekhar Natarajan, Federico G. Hoffmann, Roy E. Weber, Angela Fago, Christopher C. Witt, and Jay F. Storz

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Causes of molecular convergence and parallelism in protein evolution, Jay F. Storz

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Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport, Jay F. Storz

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Hemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?, Jay F. Storz

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Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation, Jay F. Storz and Zachary A. Cheviron

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Gene duplication, genome duplication, and the functional diversification of vertebrate globins, Jay F. Storz, Juan C. Opazo, and Federico G. Hoffmann

2015

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High-altitude ancestry and hypoxia acclimation have distinct effects on exercise capacity and muscle phenotype in deer mice, Mikela A. Lui, Sajeni Mahalingam, Paras Patel, Alex D. Connaty, Catherine M. Ivy, Zachary A. Cheviron, Jay F. Storz, Grant B. McClelland, and Graham R. Scott

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Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level, Chandrasekhar Natarajan, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Violeta Muñoz-Fuentes, Andy J. Green, Cecilia Kopuchian, Pablo L. Tubaro, Luis Alza, Mariana Bulgarella, Matthew M. Smith, Robert E. Wilson, Angela Fago, Kevin G. McCracken, and Jay F. Storz

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Ancient Duplications and Expression Divergence in the Globin Gene Superfamily of Vertebrates: Insights from the Elephant Shark Genome and Transcriptome, Juan C. Opazo, Alison P. Lee, Federico G. Hoffmann, Jessica Toloza-Villalobos, Thorsten Burmester, Byrappa Venkatesh, and Jay F. Storz

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Adaptive Modifications of Muscle Phenotype in High-Altitude Deer Mice Are Associated with Evolved Changes in Gene Regulation, Graham R. Scott, Todd S. Elogio, Mikaela A. Lui, Jay F. Storz, and Zachary A. Cheviron

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Genetic approaches in comparative and evolutionary physiology, Jay F. Storz, Jaime T. Bridgham, Scott A. Kelly, and Theodore Garland Jr.

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Oxygenation properties and isoform diversity of snake hemoglobins, Jay F. Storz, Chandrasekhar Natarajan, Hideaki Moriyama, Federico G. Hoffmann, Tobias Wang, Angela Fago, Hans Malte, Johannes Overgaard, and Roy E. Weber

2014

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Repeated Evolution of Chimeric Fusion Genes in the β-Globin Gene Family of Laurasiatherian Mammals, Michael J. Gaudry, Jay F. Storz, Gary Tyler Butts, Kevin L. Campbell, and Federico G. Hoffmann

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The Globin Gene Repertoire of Lampreys: Convergent Evolution of Hemoglobin and Myoglobin in Jawed and Jawless Vertebrates, Kim Schwarze, Kevin L. Campbell, Thomas Hankeln, Jay F. Storz, Federico G. Hoffmann, and Thorsten Burmester

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Comparative genomics reveals insights into avian genome evolution and adaptation, Guojie Zhang, Cai Li, Qiye Li, Bo Li, Dennis M. Larkin, Chul Lee, Jay F. Storz, Agostinho Antunes, Matthew J. Greenwold, Robert W. Meredith, Anders Ödeen, Jie Cui, Qi Zhou, Luohao Xu, Hailin Pan, Zongji Wang, Lijun Jin, Pei Zhang, Haofu Hu, Wei Yang, Jiang Hu, Jin Xiao, Zhikai Yang, Yang Liu, Qiaolin Xie, Hao Yu, Jinmin Lian, Ping Wen, Fang Zhang, Hui Li, Yongli Zeng, Zijun Xiong, Shiping Liu, Long Zhou, Zhiyong Huang, Na An, Jie Wang, Quimei Zheng, Yingqi Xiong, Guangbiao Wang, Bo Wang, Jingjing Wang, Yu Fan, Rute R. da Fonseca, Alonzo Alfaro-Núñez, Mikkel Schubert, Ludovic Orlando, Tobias Mourier, Jason T. Howard, Ganeshkumar Ganapathy, Andreas Pfenning, Osceola Whitney, Miriam V. Rivas, Erina Hara, Julia Smith, Marta Farré, Jitendra Narayan, Gancho Slavov, Michael N. Romanov, Rui Borges, João Paulo Machado, Imran Khan, Mark S. Springer, John Gatesy, Federico G. Hoffmann, Juan C. Opazo, Olle Håstad, Roger H. Sawyer, Heebal Kim, Kyu-Won Kim, Hyeon Jeong Kim, Seoae Cho, Ning Li, Yinhua Huang, Michael W. Bruford, Xiangjiang Zhan, Andrew Dixon, Mads F. Bertelsen, Elizabeth Derryberry, Wesley Warren, Richard K. Wilson, Shengbin Li, David A. Ray, Richard E. Green, Stephen J. O'Brien, Darren Griffin, Warren E. Johnson, David Haussler, Oliver A. Ryder, Eske Willerslev, Gary R. Graves, Per Alström, Jon Fjeldså, David P. Mindell, Scott V. Edwards, Edward L. Braun, Carsten Rahbek, David W. Burt, Peter Houde, Yong Zhang, Huanming Yang, Jian Wang, Avian Genome Consortium, Erich D. Jarvis, M. Thomas P. Gilbert, and Jun Wang

2013

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Contributions of phenotypic plasticity to differences in thermogenic performance between highland and lowland deer mice, Zachary A. Cheviron, Gwendolyn C. Bachman, and Jay F. Storz

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Functional Genomics of Adaptation to Hypoxic Cold-Stress in High-Altitude Deer Mice: Transcriptomic Plasticity and Thermogenic Performance, Zachary A. Cheviron, Alex D. Connaty, Grant B. McClelland, and Jay F. Storz

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Hemoglobin isoform differentiation and allosteric regulation of oxygen binding in the turtle, Trachemys scripta, Christian Damsgaard, Jay F. Storz, Federico G. Hoffmann, and Angela Fago

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Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin, Chandrasekhar Natarajan, Noriko Inoguchi, Roy E. Weber, Angela Fago, Hideaki Moriyama, and Jay F. Storz

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Whole-Genome Duplication and the Functional Diversification of Teleost Fish Hemoglobins, Juan C. Opazo, Gary Tyler Butts, Mariana F. Nery, Jay F. Storz, and Federico G. Hoffmann

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Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds, Joana Projecto-Garcia, Chandrasekhar Natarajan, Hideaki Moriyama, Roy E. Weber, Angela Fago, Zachary A. Cheviron, Robert Dudley, Jimmy A. McGuire, Christopher C. Witt, and Jay F. Storz

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Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges, Inge G. Revsbech, Danielle M. Tufts, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Jay F. Storz, and Angela Fago

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Phenotypic plasticity in blood–oxygen transport in highland and lowland deer mice, Danielle M. Tufts, Inge G. Revsbech, Zachary A. Cheviron, Roy E. Weber, Angela Fago, and Jay F. Storz

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Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin, Roy E. Weber, Angela Fago, Hans Malte, Jay F. Storz, and Thomas A. Gorr

2012

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Elucidating Nature’s Solutions to Heart, Lung, and Blood Diseases and Sleep Disorders, Hannah V. Carey, Sandra L. Martin, Barbara A. Horwitz, Lin Yan, Shannon M. Bailey, Jason Podrabsky, Jay F. Storz, Rudy M. Ortiz, and Renee P. Wong

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Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer mice, Zachary A. Cheviron, Gwendolyn C. Bachman, Alex D. Connaty, and Jay F. Storz

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Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds, Michael T. Grispo, Chandrasekhar Natarajan, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, and Jay F. Storz

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Evolution of the Globin Gene Family in Deuterostomes: Lineage-Specific Patterns of Diversification and Attrition, Federico G. Hoffmann, Juan C. Opazo, David Hoogewijs, Thomas Hankeln, Bettina Ebner, Serge N. Vinogradov, Xavier Bailly, and Jay F. Storz

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Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content, Jay F. Storz, Roy E. Weber, and Angela Fago

2011

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Differential Loss and Retention of Cytoglobin, Myoglobin, and Globin-E during the Radiation of Vertebrates, Federico G. Hoffmann, Juan C. Opazo, and Jay F. Storz

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Expression and Purification of Recombinant Hemoglobin in Escherichia coli, Chandrasekhar Natarajan, Xiaoben Jiang, Angela Fago, Roy E. Weber, Hideaki Moriyama, and Jay F. Storz

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Evolutionary Origins of Oxygen Sensing in Animals, Kalle T. Rytkönen and Jay F. Storz

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Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis, Jay F. Storz, Federico G. Hoffmann, Juan C. Opazo, Thomas J. Sanger, and Hideaki Moriyama

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Phylogenetic Diversification of the Globin Gene Superfamily in Chordates, Jay F. Storz, Juan C. Opazo, and Federico G. Hoffmann

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Experimental Approaches to Evaluate the Contributions of Candidate Protein-Coding Mutations to Phenotypic Evolution, Jay F. Storz and Anthony J. Zera

2010

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Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole, Kevin L. Campbell, Jay F. Storz, Anthony V. Signore, Hideaki Moriyama, Kenneth C. Catania, Alexander P. Payson, Joseph Bonaventura, Jörg Stetefeld, and Roy E. Weber

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Gene cooption and convergent evolution of oxygen transport hemoglobins in jawed and jawless vertebrates, Federico G. Hoffmann, Juan C. Opazo, and Jay F. Storz

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Lineage-Specific Patterns of Functional Diversification in the α- and β-Globin Gene Families of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz, Thomas A. Gorr, and Juan C. Opazo

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Structure and Reactivity of Hexacoordinate Hemoglobins, Smita Kakar, Federico G. Hoffmann, Jay F. Storz, Marian Fabian, and Mark S. Hargrove

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Genes for High Altitudes, Jay F. Storz

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Genetic differences in hemoglobin function between highland and lowland deer mice, Jay F. Storz, Amy M. Runck, Hideaki Moriyama, Roy E. Weber, and Angela Fago

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Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates, Jay F. Storz, Graham R. Scott, and Zachary A. Cheviron

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Integrating Evolutionary and Functional Approaches to Infer Adaptation at Specific Loci, Jay F. Storz and Christopher W. Wheat

2009

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Molecular evolution of cytochrome b in high- and low-altitude deer mice (genus Peromyscus), E. J. Gering, J. C. Opazo, and Jay F. Storz

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Origin and Ascendancy of a Chimeric Fusion Gene: The β/δ-Globin Gene of Paenungulate Mammals, Juan C. Opazo, Angela M. Sloan, Kevin L. Campbell, and Jay F. Storz

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Evolution of Duplicated β-Globin Genes and the Structural Basis of Hemoglobin Isoform Differentiation in Mus, Amy M. Runck, Hideaki Moriyama, and Jay F. Storz

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Gene Duplication and the Resolution of Adaptive Conflict, Jay F. Storz

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Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin, Jay F. Storz, Amy M. Runck, Stephen J. Sabatino, John K. Kelly, Nuno Ferrand, Hideaki Moriyama, Roy E. Weber, and Angela Fago

2008

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Evidence for contrasting modes of selection at interacting globin genes in the European rabbit (Oryctolagus cuniculus), R. Campos, Jay F. Storz, and N. Ferrand

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Molecular evolution of cytochrome b in high- and low-altitude deer mice (genus Peromyscus), E.J. Gering, J. C. Opazo, and Jay F. Storz

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Rapid Rates of Lineage-Specific Gene Duplication and Deletion in the α-Globin Gene Family, Federico G. Hoffmann, Juan C. Opazo, and Jay F. Storz

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New Genes Originated via Multiple Recombinational Pathways in the β-Globin Gene Family of Rodents, Frederico Hoffmann, Juan Opazo, and Jay F. Storz

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Genomic evidence for independent origins of β-like globin genes in monotremes and therian mammals, Juan C. Opazo, Federico G. Hoffmann, and Jay F. Storz

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Differential loss of embryonic globin genes during the radiation of placental mammals, Juan C. Opazo, Federico Hoffmann, and Jay F. Storz

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Adaptive Functional Divergence among Triplicated α-Globin Genes in Rodents, Jay F. Storz, Federico G. Hoffmann, Juan C. Opazo, and Hideaki Moriyama

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Effects of Spatially Varying Selection on Nucleotide Diversity and Linkage Disequilibrium: Insights From Deer Mouse Globin Genes, Jay F. Storz and John K. Kelly

2007

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The αD-Globin Gene Originated via Duplication of an Embryonic α-Like Globin Gene in the Ancestor of Tetrapod Vertebrates, Federico G. Hoffmann and Jay F. Storz

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HEMOGLOBIN FUNCTION AND PHYSIOLOGICAL ADAPTATION TO HYPOXIA IN HIGH-ALTITUDE MAMMALS, Jay F. Storz

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Complex Signatures of Selection and Gene Conversion in the Duplicated Globin Genes of House Mice, Jay F. Storz, Monica Baze, Jessica L. Waite, Federico G. Hoffmann, Juan C. Opazo, and Jack P. Hayes

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THE STUDY OF ADAPTATION AND SPECIATION IN THE GENOMIC ERA, Jay F. Storz and Hopi E. Hoekstra

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Supporting Information for "The Molecular Basis of High-Altitude Adaptation in Deer Mice", Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, and Michael W. Nachman

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The Molecular Basis of High-Altitude Adaptation in Deer Mice, Jay F. Storz, Stephen J. Sabatino, Federico G. Hoffmann, Eben J. Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, and Michael W. Nachman

2006

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Evolutionary Dynamics of the Short-Nosed Fruit Bat, Cynopterus sphinx (Pteropodidae): Inferences from the Spatial Scale of Genetic and Phenotypic Differentiation, Jay F. Storz, Hari R. Bhat, Johnson Balasingh, P. Thiruchenthil Nathan, and Thomas H. Kunz

2005

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Nonrandom dispersal and local adaptation, Jay F. Storz

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Using genome scans of DNA polymorphism to infer adaptive population divergence, Jay F. Storz

2004

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Estimation of genetically effective breeding numbers using a rejection algorithm approach, Uma Ramakrishnan, Jay F. Storz, Barbara L. Taylor, and Russell Lande

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Natural Selection Drives Altitudinal Divergence at the Albumin Locus in Deer Mice, Peromyscus Maniculatus, Jay F. Storz and Jean M. Dubach

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Genome Scans of DNA Variability in Humans Reveal Evidence for Selective Sweeps Outside of Africa, Jay F. Storz, Bret A. Payseur, and Michael W. Nachman

2003

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Natural Selection on Protein Polymorphism in the Rodent Genus Peromyscus: Evidence from Interlocus Contrasts, Jay F. Storz and Michael W. Nachman

2002

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Contrasting Patterns of Divergence in Quantitative Traits and Neutral DNA Markers: Analysis of Clinal Variation, Jay F. Storz

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Testing for Genetic Evidence of Population Expansion and Contraction: An Empirical Analysis of Microsatellite DNA Variation Using a Hierarchical Bayesian Model, Jay F. Storz and Mark Beaumont

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Genetic Evidence for Long-Term Population Decline in a Savannah Dwelling Primate: Inferences from a Hierarchical Bayesian Model, Jay F. Storz, Mark A. Beaumont, and Susan C. Alberts

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Genetic Effective Size of a Wild Primate Population: Influence of Current and Historical Demography, Jay F. Storz, Uma Ramakrishnan, and Susan C. Alberts

2001

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Clinal variation in body size and sexual dimorphism in an Indian fruit bat, Cynopterus sphinx (Chiroptera: Pteropodidae), Jay F. Storz, J. Balasingh, Hari Bhat, P. Thiruchenthil Nathan, D. Paramanantha Swami Doss, A. Antony Prakash, and Thomas H. Kunz

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Genetic Consequences of Polygyny and Social Structure in an Indian Fruit Bat, Cynopterus sphinx. I. Inbreeding, Outbreeding, and Population Subdivision, Jay F. Storz, Hari Bhat, and Thomas Kunz

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Genetic Consequences of Polygyny and Social Structure in an Indian Fruit Bat, Cynopterus sphinx. II. Variance in Male Mating Success and Effective Population Size, Jay F. Storz, Hari Bhat, and Thomas H. Kunz

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Determinants of Effective Population Size for Loci with Different Modes of Inheritance, Jay F. Storz, U. Ramakrishnan, and S. C. Alberts

2000

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Variation at tri- and tetranucleotide repeat microsatellite loci in the fruit bat genus Cynopterus (Chiroptera: Pteropodidae), Jay F. Storz

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Dispersion and site fidelity in a tent-roosting population of the short-nosed fruit bat (Cynopterus sphinx) in southern India, Jay F. Storz, J. Balasingh, P. Thiruchenthil Nathan, K. Emmanuel, and Thomas H. Kunz

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Social structure of a polygynous tent-making bat, Cynopterus sphinx (Megachiroptera), Jay F. Storz, Hari Bhat, and Thomas H. Kunz

1999

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Genetic Consequences of Mammalian Social Structure, Jay F. Storz

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Cynopterus sphinx, Jay F. Storz and Thomas H. Kunz

1997

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Selective Feeding by Phyllostomid Fruit Bats in a Subtropical Montane Cloud Forest, David Herníndez-Conrique, Luis Iñiguez-Dávalos, and Jay F. Storz