Bionanotechnology and the Future of Glioma

Authors

Peter A. Chiarelli, University of Washington, SeattleFollow
Forrest M. Kievit, University of Washington, SeattleFollow
Miqin Zhang, University of Washington, SeattleFollow
Richard G. Ellenbogen, University of Washington, SeattleFollow

Date of this Version

2015

Citation

SNI: Neuro-Oncology 2015, Vol 6, Suppl 1

Comments

Copyright: © 2015 Chiarelli PA.

Open access

DOI: 10.4103/2152-7806.151334

Abstract

Designer nanoscaled materials have the potential to revolutionize diagnosis and treatment for glioma. This review summarizes current progress in nanoparticle‑based therapies for glioma treatment including targeting, drug delivery, gene delivery, and direct tumor ablation. Preclinical and current human clinical trials are discussed. Although progress in the field has been significant over the past decade, many successful strategies demonstrated in the laboratory have yet to be implemented in human clinical trials. Looking forward, we provide examples of combined treatment strategies, which harness the potential for nanoparticles to interact with their biochemical environment, and simultaneously with externally applied photons or magnetic fields. We present our notion of the “ideal” nanoparticle for glioma, a concept that may soon be realized.