Biological Systems Engineering, Department of
Document Type
Article
Date of this Version
2015
Citation
SNI: Neuro-Oncology 2015, Vol 6, Suppl 1
Abstract
Designer nanoscaled materials have the potential to revolutionize diagnosis and treatment for glioma. This review summarizes current progress in nanoparticle‑based therapies for glioma treatment including targeting, drug delivery, gene delivery, and direct tumor ablation. Preclinical and current human clinical trials are discussed. Although progress in the field has been significant over the past decade, many successful strategies demonstrated in the laboratory have yet to be implemented in human clinical trials. Looking forward, we provide examples of combined treatment strategies, which harness the potential for nanoparticles to interact with their biochemical environment, and simultaneously with externally applied photons or magnetic fields. We present our notion of the “ideal” nanoparticle for glioma, a concept that may soon be realized.
Included in
Bioresource and Agricultural Engineering Commons, Environmental Engineering Commons, Other Civil and Environmental Engineering Commons
Comments
Copyright: © 2015 Chiarelli PA.
Open access
DOI: 10.4103/2152-7806.151334