Multipolymer microsphere delivery of SARS-CoV-2 antigens

Authors

Farah Shahjin, University of Nebraska Medical Center
Milankumar Patel, University of Nebraska Medical Center
Jatin Machhi, University of Nebraska Medical Center
Jacob D. Cohen, University of Nebraska Medical Center
Mohammad Ullah Nayan, University of Nebraska Medical Center
Pravin Yeapuri, University of Nebraska Medical Center
Chen Zhang, University of Nebraska Medical Center
Emiko Waight, University of Nebraska Medical Center
Mahmudul Hasan, University of Nebraska Medical Center
Mai Mohamed Abdelmoaty, University of Nebraska Medical Center
Prasanta K. Dash, University of Nebraska Medical Center
You Zhou, University of Nebraska - LincolnFollow
Irene Andreu, University of Rhode Island
Howard E. Gendelman, University of Nebraska Medical Center
Bhavesh D. Kevadiya, University of Nebraska Medical Center

Date of this Version

12-26-2022

Document Type

Article

Citation

Acta Biomaterialia 158 (2023) 493–509. https://doi.org/10.1016/j.actbio.2022.12.043

Comments

Open access.

Abstract

Effective antigen delivery facilitates antiviral vaccine success defined by effective immune protective re- sponses against viral exposures. To improve severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) antigen delivery, a controlled biodegradable, stable, biocompatible, and nontoxic polymeric micro- sphere system was developed for chemically inactivated viral proteins. SARS-CoV-2 proteins encapsulated in polymeric microspheres induced robust antiviral immunity. The viral antigen-loaded microsphere sys- tem can preclude the need for repeat administrations, highlighting its potential as an effective vaccine.