Multipolymer microsphere delivery of SARS-CoV-2 antigens

Authors

• Farah Shahjin, University of Nebraska Medical Center
• Milankumar Patel, University of Nebraska Medical Center
• Jatin Machhi, University of Nebraska Medical Center
• Jacob D. Cohen, University of Nebraska Medical Center
• Mohammad Ullah Nayan, University of Nebraska Medical Center
• Pravin Yeapuri, University of Nebraska Medical Center
• Chen Zhang, University of Nebraska Medical Center
• Emiko Waight, University of Nebraska Medical Center
• Mahmudul Hasan, University of Nebraska Medical Center
• Mai Mohamed Abdelmoaty, University of Nebraska Medical Center
• Prasanta K. Dash, University of Nebraska Medical Center
• You Zhou, University of Nebraska - LincolnFollow
• Irene Andreu, University of Rhode Island
• Howard E. Gendelman, University of Nebraska Medical Center
• Bhavesh D. Kevadiya, University of Nebraska Medical Center

Document Type

Article

Date of this Version

12-26-2022

Citation

Acta Biomaterialia 158 (2023) 493–509. https://doi.org/10.1016/j.actbio.2022.12.043

Comments

Open access.

Abstract

Effective antigen delivery facilitates antiviral vaccine success defined by effective immune protective re- sponses against viral exposures. To improve severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) antigen delivery, a controlled biodegradable, stable, biocompatible, and nontoxic polymeric micro- sphere system was developed for chemically inactivated viral proteins. SARS-CoV-2 proteins encapsulated in polymeric microspheres induced robust antiviral immunity. The viral antigen-loaded microsphere sys- tem can preclude the need for repeat administrations, highlighting its potential as an effective vaccine.