Published Research - Department of Chemistry

 

Date of this Version

6-22-2012

Citation

Chem Biol. 2012 June 22; 19(6): 666–667. doi:10.1016/j.chembiol.2012.06.005.

Comments

Copyright 2012. Used by permission.

Abstract

In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.

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