Combinatorial Catalysis Assisted by a Visible Enzymatic Beacon in Real Time: New Synthetically Versatile (Pseudo)Halometalation/Carbocyclizations

Authors

• Jacob A. Friest, University of Nebraska - Lincoln
• Sylvain Broussy, University of Nebraska-LincolnFollow
• Woo Jin Chung, University of Nebraska - Lincoln
• David B. Berkowitz, University of Nebraska - LincolnFollow

Document Type

Article

Date of this Version

9-12-2011

Citation

Angew Chem Int Ed Engl. 2011 September 12; 50(38): 8895–8899. doi:10.1002/anie.201103365.

Comments

Copyright 2011. Used by permission.

Abstract

Combinatorial approaches to catalysis have made an impact in targeted transformation development, including Ag-mediated carbene insertion,^[1] Sc-pybox-based asymmetric cyclopropanation,^[2] and Rh/Ir-based asymmetric hydrogenation.^[3] Useful design elements have emerged from these studies, e.g. the value of ligand self assembly,^[4] or of the inclusion of peptide-like structural elements^[5],[6],[7] in building ligand arrays. Efficient screening methods are of paramount importance for such efforts. Methods based on fluorescence,^[8] REMPI^,[9] MS,^[10] NMR,^[11] and IR thermography^[12] have appeared. A chromophore may be installed into the substrate^[13] or product^[14] of the reaction under study. Alternatively, one can exploit chromophores inherent in proteins^[15] or enzyme-associated reactions,^[16] and use these sensors to report back on product formation and composition.