Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis

Authors

Gregory A. Applegate, University of Nebraska–LincolnFollow
David B. Berkowitz, University of Nebraska-LincolnFollow

Date of this Version

2015

Citation

Published in Advanced Synthesis & Catalysis 357 (2015), pp. 1619 –1632; doi 10.1002/adsc.201500316

Comments

Copyright © 2015 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. Used by permission.

Abstract

Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to “deracemize” building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.