Chemistry, Department of: Faculty Series
David Berkowitz Publications
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Document Type
Article
Date of this Version
2015
Citation
Published in Advanced Synthesis & Catalysis 357 (2015), pp. 1619 –1632; doi 10.1002/adsc.201500316
Abstract
Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to “deracemize” building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.
Comments
Copyright © 2015 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. Used by permission.