Catabolite Control Protein E (CcpE) Is a LysR-type Transcriptional Regulator of Tricarboxylic Acid Cycle Activity in Staphylococcus aureus

Authors

• Torsten Hartmann, University of Saarland
• Bo Zhang, University of Nebraska-LincolnFollow
• Grégory Baronian, Université Montpellier
• Bettina Schulthess, University of Zürich
• Dagmar Homerova, Slovak Academy of Sciences
• Stephanie Grubmuller, Technische Universitat Munchen
• Erika Kutzner, Technische Universitat Munchen
• Rosmarie Gaupp, University of Nebraska-Lincoln
• Ralph Bertram, University of Tubingen
• Robert Powers, University of Nebraska-LincolnFollow
• Karen M. Eisenreich, Technische Universityt Munchen
• Jan Kormanec, Slovak Academy of Sciences
• Mathias Herrmann, University of Saarland
• Virginie Molle, Université Montpellier
• Greg A. Somerville, University of Nebraska-LincolnFollow
• Markus Bischoff, University of SaarlandFollow

Document Type

Article

Date of this Version

2013

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 50, pp. 36116–36128

Comments

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: The TCA cycle is a central metabolic pathway that facilitates the adaption of bacteria to a nutrient-limited environment.

Results: Inactivation of CcpE in Staphylococcus aureus resulted in a decreased transcription of the aconitase encoding gene citB, and reduced TCA cycle activity.

Conclusion: CcpE affects the TCA cycle via direct transcriptional control of citB.

Significance: This is the first positive regulator of TCA cycle activity identified in this pathogen.