Exploiting Self-Assembly for Ligand-Scaffold Optimization: Substrate-Tailored Ligands for Efficient Catalytic Asymmetric Hydroboration

Authors

Shin A. Moteki, University of Nebraska - Lincoln
James M. Takacs, University of Nebraska-LincolnFollow

Date of this Version

December 2007

Comments

Published in Angewandte Chemie Int. Ed. 46 (2007); doi: 10.1002/anie.200703127 Online at http://www3.interscience.wiley.com/cgi-bin/abstract/117870359/ABSTRACT Copyright © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Used by permission.

Abstract

A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asymmetric hydroboration (nbd = 2,5norbornadiene, R* is a chiral substituent). Ligand-scaffold optimization reveals “substrate-tailored” ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives.

Includes article (4 pp.) and supporting information (106 pp.).