Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 34, pp. 23745–23752
Background: Mitotic progression is regulated by reversible protein phosphorylation involving kinases and phosphatases.
Results: Pnuts functions as a master regulator of mitosis by modulating PP1; Pnuts expression peaks in mitosis and is degraded at mitotic exit.
Conclusion: This study reveals the function and regulation of a new and essential mitotic regulator.
Significance: This study improves our understanding of M-phase regulation.