Phosphatase 1 Nuclear Targeting Subunit Is an Essential Regulator of M-phase Entry, Maintenance, and Exit

Authors

Laura A. Fisher, University of Nebraska Medical Center
Ling Wang, University of Nebraska Medical Center
Lan Wu, Shanghai Jiao Tong University School of Medicine
Aimin Peng, University of Nebraska Medical Center, LincolnFollow

Document Type

Article

Date of this Version

2014

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 34, pp. 23745–23752

Comments

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: Mitotic progression is regulated by reversible protein phosphorylation involving kinases and phosphatases.

Results: Pnuts functions as a master regulator of mitosis by modulating PP1; Pnuts expression peaks in mitosis and is degraded at mitotic exit.

Conclusion: This study reveals the function and regulation of a new and essential mitotic regulator.

Significance: This study improves our understanding of M-phase regulation.