Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal Rats

Authors

Rebekah C. Kennedy, University of Tennessee, Knoxville
Russell R. Fling, University of Tennessee, Knoxville
Michael S. Robeson, Colorado State University
Arnold M. Saxton, University of Tennessee, KnoxvilleFollow
Robert L. Donnell, University of Tennessee, Knoxville
John L. Darcy, University of Colorado, Boulder
David A. Bemis, University of Tennessee, KnoxvilleFollow
Jiang Liu, University of Tennessee, Knoxville
Ling Zhao, University of Tennessee Knoxville
Jiangang CHen, University of Tennessee Knoxville

Date of this Version

2017

Citation

Scientific Reports, 6:33430, DOI: 10.1038/srep33430

Comments

This work is licensed under a Creative Commons Attribution 4.0 International License

Abstract

Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring. TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac distances, TCC induced significant dysbiosis of gut microbiota by gestational day (GD) 18, a trend that continued after delivery. Similarly, an overall restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, communities separated based on exposure status and became significantly different at PND 16. The ability of TCC to drive microbial dysbiosis warrants future investigation to evaluate the safety of nonprescription antimicrobial use, including TCC, during critical exposure windows.